| GAD65 | IA-2 | Insulin | |
| Amino acid length | 585 | 979 | 51 |
| Molecular weight | 65.000 | 106.000 | 6.000 |
| Chromosome | 10p11 | 2q35 | 11p15 |
|
Cell Type in which expressed |
Neuroendocrine Pancreatic islet cells |
Neuroendocrine Pancreatic islet cells |
Pancreatic islet ß-cells |
| Intracellular location | Neuron-like small vesicles | Secretory vesicles | Secretory vesicles |
| Function |
Converts glutamic acid to GABA: Inhibitory neurotransmitter |
Enzymatically inactive member of PTP family |
Ligand for the insulin receptor; regulation of blood glucose |
GABA: Gamma-Aminobutyric-Acid
PTP: Protein Tyrosine Phosphatase
Autoantikörper gegen diese 3 DM I – assoziierten Antigene werden in unserem Labor bestimmt.